Decreased Basal Ganglia Volume in Cerebral Amyloid Angiopathy

Decreased Basal Ganglia Volume in Cerebral Amyloid Angiopathy

Background and Purpose Cerebral amyloid angiopathy (CAA) is a common pathology of the leptomeningeal and cortical small vessels associated with hemorrhagic and non-hemorrhagic brain injury. Given previous evidence for CAA-related loss of cortical thickness and white matter volume, we hypothesized th...

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Veröffentlicht in:Journal of stroke 2021, 23(2), 17, pp.223-233
Hauptverfasser: Fotiadis, Panagiotis, Pasi, Marco, Charidimou, Andreas, Warren, Andrew D., Schwab, Kristin M., Rosand, Jonathan, Grond, Jeroen van der, Buchem, Mark A. van, Viswanathan, Anand, Gurol, M. Edip, Greenberg, Steven M.
Format: Artikel
Sprache:eng
Schlagworte:
atrophy
basal ganglia
cerebral amyloid angiopathy
cognition
diffusion
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신경과학
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Zusammenfassung:Background and Purpose Cerebral amyloid angiopathy (CAA) is a common pathology of the leptomeningeal and cortical small vessels associated with hemorrhagic and non-hemorrhagic brain injury. Given previous evidence for CAA-related loss of cortical thickness and white matter volume, we hypothesized that CAA might also cause tissue loss in the basal ganglia.Methods We compared basal ganglia volumes expressed as a percentage of total intracranial volume (pBGV) of non-demented patients with sporadic and hereditary CAA to age-matched healthy control (HC) and Alzheimer’s disease (AD) cohorts.Results Patients with sporadic CAA had lower pBGV (n=80, 1.16%±0.14%) compared to HC (n=80, 1.30%±0.13%, P
ISSN:2287-6391
2287-6405
DOI:10.5853/jos.2020.04280