Synthesis of Spirooxindoles Bearing 1,3‐Oxathiolane‐2‐thione Moiety From Isatin‐Derived Propargylic Alcohols
Spirooxindoles bearing 1,3‐oxathiolane‐2‐thione moiety were synthesized from isatin‐derived propargylic alcohols and carbon disulfide in the presence of 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU). The spirooxindoles were formed stereoselectively via attack of the alkoxide of propargylic alcohol to car...
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Veröffentlicht in: | Bulletin of the Korean Chemical Society 2021, 42(3), , pp.429-434 |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Spirooxindoles bearing 1,3‐oxathiolane‐2‐thione moiety were synthesized from isatin‐derived propargylic alcohols and carbon disulfide in the presence of 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU). The spirooxindoles were formed stereoselectively via attack of the alkoxide of propargylic alcohol to carbon disulfide to form xanthate anion and a following 5‐exo‐dig cyclization process.
Synthesis of spirooxindoles bearing 1,3‐oxathiolane‐2‐thione moiety. |
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ISSN: | 1229-5949 0253-2964 1229-5949 |
DOI: | 10.1002/bkcs.12206 |