Treadmill exercise in obese maternal rats during pregnancy improves short-term memory through neurogenesis in the hippocampus of rat pups

Maternal obesity is known to increase the likelihood of offspring be-coming obese, high blood pressure, and other metabolic disorders. Af-ter inducing obesity, the effect of treadmill exercise in maternal rats during pregnancy on short-term memory was investigated in relation to neurogenesis in rat...

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Veröffentlicht in:Journal of exercise rehabilitation 2020, 16(5), 69, pp.392-397
Hauptverfasser: Ji, Eun-Sang, Kim, You-Mi, Ko, Young Jun, Baek, Seung-Soo
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Sprache:eng
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Zusammenfassung:Maternal obesity is known to increase the likelihood of offspring be-coming obese, high blood pressure, and other metabolic disorders. Af-ter inducing obesity, the effect of treadmill exercise in maternal rats during pregnancy on short-term memory was investigated in relation to neurogenesis in rat pups. Short-term memory was declined in rat pups born to obese maternal rats, and treadmill running during pregnancy al-leviated short-term memory impairment in rat pups born to obese ma-ternal rats. The number of doublecortin (DCX)-positive and 5-bro-mo-2′-deoxyuridine (BrdU)-positive cells in the hippocampal dentate gyrus was decreased in rat pups born to obese maternal rats. Treadmill running during pregnancy increased the number of DCX-positive and BrdU-positive cells in rat pups born to obese maternal rats. Expression of brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) in the hippocampus was decreased in the rat pups born to obese maternal rats. Treadmill running during pregnancy increased the ex-pressions of BDNF and TrkB in rat pups born to obese maternal rats. Enhancing effect of short-term memory by treadmill exercise may be due to increased neurogenesis through activation of the BDNF-TrkB signaling pathway by treadmill exercise.
ISSN:2288-176X
2288-1778
DOI:10.12965/jer.2040618.309