Hepatoprotective effects of Meconopsis aculeata extract against CCl4 induced oxidative damage in rats

The objective of the present study was to investigate the hepatoprotective effects of methanol extract of Meconopsis aculeata , an important medicinal plant of Kashmir Himalayas, against CCl 4 induced oxidative damage in rats. Acute hepatotoxicity was induced in Wistar albino rats by single intraperitoneal injection of CCl 4 at 1 ml/kg body weight dose. Methanol extract of M. aculeata was orally administered at the doses of 100, 200 and 300 mg/kg body weight/day for 14 days. The results revealed that administration of CCl 4 caused a significant increase in serum AST, ALT and LDH levels as compared to the control group ( p