A Suggestion on the Action Mechanisms of Acupuncture Treatment for Controlling Chemotherapy-Induced Peripheral Neuropathy

Objectives: The purpose of this study is to investigate the mechanism of acupuncture for treating chemotherapy -induced peripheral neuropathy. Methods: Based on domestic and international papers reported until October 2020, experimental papers on “chemotherapy induced peripheral neuropathy”, “mechanism”, and “acupuncture” were set up to identify the mechanisms of chemotherapy induced peripheral neuropathy. A total of seven papers were selected and searched: one pilot paper for people and six experimental papers for rats. Results: In the pilot paper studied by Bao, T., the effect of EA was demonstrated but no significant results were produced for the mechanism. Moon et al. derived the association between EA and plasma β–endorphin in rat experimental studies on oxalilatin-induced cold hypersensitivity. Meng et al. found relevance to μ, δ, and δ opioid through EA stimulation in paclitaxel-induced peripheral neuropathy. Lee et al. studied the relationship between EA and muscarin and 5-HT in rat experiments on oxaliplatin-induced coldness, associated with 5-HT and EA, especially with 5-HT3 receptors. Choi et al. revealed the association of adrenaline and opioid acting on α2- and β adrenaline receptors with EA in rat experiments on paclitaxel-induced neuralgia. In rat experiments on oxaliplatin-induced neuralgia reported by Lee, β-endorphin and encephalin were studied to be mediated by EA. Zhang, T. et al. revealed in the paclitaxel induced rat experiment that EA activates 5-HT. Conclusion: It is inferred that peripheral neuropathy caused by anticancer drugs can be reduced by activating the action of 5-HT, β-endorphin, and encephalin through the descending inhibitory pathways. cell differentiation, herbal medicine, Pongamia, stem cells KCI Citation Count: 0