Rose Petal Extract ( Rosa gallica ) Exerts Skin Whitening and Anti-Skin Wrinkle Effects

We sought to investigate the effect of extracts from petals (RPE) on skin whitening and anti-wrinkle activity. Tyrosinase activity was attenuated by RPE treatment, concomitant with the reduction of melanin accumulation in human B16F10 melanoma. Treatment of the facial skin of volunteers in a clinica...

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Veröffentlicht in:Journal of medicinal food 2020, 23(8), , pp.870-878
Hauptverfasser: Song, Young-Ran, Lim, Won-Chul, Han, Ahram, Lee, Myung-Hee, Shin, Eun Ju, Lee, Kwang-Min, Nam, Tae-Gyu, Lim, Tae-Gyu
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Sprache:eng
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Zusammenfassung:We sought to investigate the effect of extracts from petals (RPE) on skin whitening and anti-wrinkle activity. Tyrosinase activity was attenuated by RPE treatment, concomitant with the reduction of melanin accumulation in human B16F10 melanoma. Treatment of the facial skin of volunteers in a clinical trial with an RPE-containing formulation enhanced skin brightness (L* value) significantly. The underlying mechanism responsible was determined to be associated with mitogen-activated protein kinase (MAPK) activation. In addition, RPE exhibited anti-wrinkle formation activity of human dermal fibroblasts by suppressing matrix metalloproteinase (MMP)-1 level. study, RPE also inhibited solar ultraviolet-stimulated MMP-1 level by c-Jun regulation. Overall, our findings indicate that RPE evokes skin whitening and anti-wrinkle formation activity by regulating intracellular signaling, supporting its utility as an ingredient for skin whitening and anti-wrinkle cosmetic products.
ISSN:1096-620X
1557-7600
DOI:10.1089/jmf.2020.4705