The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies

As an essential nutrient and trace element, selenium is required for living organisms and its beneficial roles in human health have been well recognized. The role of selenium is mainly played through selenoproteins synthesized by the selenium metabolic system. Selenoproteins have a wide range of cellular functions including regulation of selenium transport, thyroid hormones, immunity, and redox homeostasis. Selenium deficiency contributes to various diseases, such as cardiovascular disease, cancer, liver disease, and arthropathy—Kashin–Beck disease (KBD) and osteoarthritis (OA). A skeletal developmental disorder, KBD has been reported in low-selenium areas of China, North Korea, and the Siberian region of Russia, and can be alleviated by selenium supplementation. OA, the most common form of arthritis, is a degenerative disease caused by an imbalance in matrix metabolism and is characterized by cartilage destruction. Oxidative stress serves as a major cause of the initiation of OA pathogenesis. Selenium deficiency and dysregulation of selenoproteins are associated with impairments to redox homeostasis in cartilage. We review the recently explored roles of selenium metabolism and selenoproteins in cartilage with an emphasis on two arthropathies, KBD and OA. Moreover, we discuss the potential of therapeutic strategies targeting the biological functions of selenium and selenoproteins for OA treatment. Joint health: the rare micronutrient selenium may be crucial Selenium, a micronutrient found in brazil nuts, shiitake mushrooms, and most meats, may aid in treating joint diseases, including the most common form of arthritis, osteoarthritis (OA). In addition to thyroid hormone metabolism and immunity, selenium is important in antioxidant defense. Oxidative damage can destroy cartilage and harm joints, and selenium deficiency is implicated in several joint diseases. Jin-Hong Kim at Seoul National University in South Korea and co-workers reviewed selenium metabolism, focusing on OA and and Kashin–Beck disease, a skeletal development disorder prevalent in selenium-deficient areas of northeast Asia. They report that selenium-containing proteins protect cells against oxidative damage and that selenium is crucial to cartilage production. Further investigation of selenium metabolism may point the way to new treatments for OA and other joint diseases.