Preparation and Characterization of Bis-ethylhexyloxyphenolmethoxyphenyltriazine (BEMT) Loaded Solid Lipid Nano-particles (SLN)

Bis-ethylhexyloxyphenolmethoxyphenyltriazine (BEMT) is one of the most widely used chemical UVA+UVB double absorbers in sunscreen products. The purpose of this study is to establish the characterization of solid lipid nano-particles containing BEMT (BEMT-SLNs) within a sunscreen agent. For this experimental study, the external micrographs of the SLNs show that they are usually spherical, nonporous and uniform with a smooth surface. The particle’s diameter varied between about 330 to 500 nm and the encapsulation efficiencies ranged from 77.8 to 89.2 %. The diameter of BEMT particle encapsulated by solid lipid capsules with 50 wt% polyol content decreased to 330 nm compared to 20 wt%, but the loading capacity did not change. It can be ascertained that BEMTSLNs shows a small third peak indicating the βi form and a lower crystallinity index (C.I.) value. The residual BEMT content gradually decreased to 80.9 % over 12 h as a result of UV radiation, but the residual BEMT content with an encapsulated solid lipid decreased only to 92.3 %. The SLN improve photochemical stability of BEMT in the sunscreen products. KCI Citation Count: 17