Calcium phosphate-mediated surface modification of titanium oxide and its effects on surface potential and fibrinogen adsorption

Surface modification is one of major concerns in biomaterial research for the improvement of biocompatibility. This study examined the effects of calcium phosphate (CaP) formation on TiO2 particle on the surface properties and adsorption of fibrinogen (FBN). CaP coating was formed by incubating the particles in an ionic solution. The properties of CaP-coated TiO2 (cpTiO2) were analyzed using various analytical methods. CaP coating was calcium-deficient showing a highly porous 3D structure and decreased the negativity of zeta potential of the particle. Fibrinogen (FBN) adsorption decreased the negativity of the surface charge of particles dependent on FBN adsorption time and concentration.