허브 식물 4종의 1,1-Diphenyl-2-Picrylhydrazyl 라디칼 소거능, 세포 독성 및 tyrosinase 저해활성 검정

Abstract The present study was conducted to evaluate of the 1,1-Diphenyl-2-Picrylhydrazyl (DPPH) radical scavenging effect, cytotoxicity and tyrosinase inhibition activities using methanol extracts from different parts of four herb plants. The results showed that whole and root extracts of yarrow the highest total polyphenol and flavonoid contents as well as whole of yarrow revealed the highest DPPH radical scavenging effect. In cytotoxicity test against three cancer cell lines, HeLa (uterus), SK-Hep-1 (liver), and YD-15 (oral), the whole extract of feverfew showed the highest toxicity with IC50 values of 102.58-138.68 μg/mL. Also, mallow root extract (71.24 μg/mL) exhibited potent tyrosinase inhibitory activity comparable to arbutin (69.56 μg/mL), which was used as the control.