Pharmacokinetic Study of Florfenicol in Healthy and Vibriosis-infected Pseudosciaena crocea after Oral Administration

The pharmacokinetics of florfenicol were studied in healthy and vibriosis-infected large yellow croaker (Pseudosciaena crocea) following administration of a single oral dose of 20 mg·kg−1 at 25±2oC. After oral administration, florfenicol levels in tissues (liver, kidney, muscle, serum, and skin) wer...

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Veröffentlicht in:Journal of applied biological chemistry 2015, 58(4), , pp.363-368
Hauptverfasser: Wang, Li, Han, Yan-nan, Jin, Shan, Ma, Yin, Wang, Guo-liang, Zhao, Qing-song, Chen, Yin-er
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Sprache:eng
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Zusammenfassung:The pharmacokinetics of florfenicol were studied in healthy and vibriosis-infected large yellow croaker (Pseudosciaena crocea) following administration of a single oral dose of 20 mg·kg−1 at 25±2oC. After oral administration, florfenicol levels in tissues (liver, kidney, muscle, serum, and skin) were analyzed using high-performance liquid chromatography. A two-compartment open model was used to describe the pharmacokinetics of florfenicol following oral administration. Compared to the healthy group, the absorption rate of vibriosis-infected fish significantly decreased, peak-time (Tmax) delayed, maximum concentration (Cmax) declined, total body clearance decreased, the elimination half-life (T1/2β) was extended, and the area under the curve increased. These results indicate that a 20 mg·kg−1 oral dose of florfenicol administered once daily continuously for 4 or 5 days can be used for the treatment of Vibrio alginolyticus infection in large yellow croaker (Pseudosciaena crocea). KCI Citation Count: 0
ISSN:1976-0442
2234-7941
DOI:10.3839/jabc.2015.057