Neuroprotective Effect of Hericium erinaceum against Oxidative Stress on PC12 Cells

Neuroprotective Effect of Hericium erinaceum against Oxidative Stress on PC12 Cells

The free radical scavenging activity of various enzymatic extracts prepared from Hericium erinaceum was evaluated by using an ESR spectrometer. For this study, H. erinaceum was enzymatically hydrolyzed by eight carbohydrases and eight proteases. All of the hydrolyzed extracts scavenged DPPH, hydroxy...

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Veröffentlicht in:Applied biological chemistry 2010, 53(3), , pp.283-289
Hauptverfasser: Lee, S.J., Konkuk University, Chungju, Republic of Korea, Kim, E.K., Konkuk University, Chungju, Republic of Korea, Hwang, J.W., Konkuk University, Chungju, Republic of Korea, Kim, C.G., Konkuk University, Chungju, Republic of Korea, Choi, D.K., Konkuk University, Chungju, Republic of Korea, Lim, B.O., Konkuk University, Chungju, Republic of Korea, Moon, S.H., Konkuk University, Chungju, Republic of Korea, Jeon, B.T., Konkuk University, Chungju, Republic of Korea, Park, P.J., Konkuk University, Chungju, Republic of Korea
Format: Artikel
Sprache:eng
Schlagworte:
antioxidative activity
Applied Microbiology
Bcl-2 protein
Biological Techniques
Bioorganic Chemistry
Carbohydrases
Chemistry
Chemistry and Materials Science
enzymatic hydrolysates
FREE RADICALS
Hericium erinaceum
Hericium erinaceus
Hydrogen peroxide
Hydroxyl radicals
Neuroprotection
neuroprotective effect
Oxidation
Oxidative stress
Pheochromocytoma cells
RADICAL LIBRE
RADICALES LIBRES
Scavenging
Superoxide
농학
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Zusammenfassung:The free radical scavenging activity of various enzymatic extracts prepared from Hericium erinaceum was evaluated by using an ESR spectrometer. For this study, H. erinaceum was enzymatically hydrolyzed by eight carbohydrases and eight proteases. All of the hydrolyzed extracts scavenged DPPH, hydroxyl, superoxide, and alkyl radicals. Especially, the the pepsin-treated extracts (PTE) exhibited the highest scavenging activity on hydroxyl radical, which is deemed of the strongest radical. Also, the neuroprotective effects of PTE against hydrogen peroxide induced oxidative stress in PC12 cells were investigated. PTE stimulated the expression of Bcl-2, on the contrary, the extracts suppressed the expression of Bax. These results indicate that PTE possess antioxidative activity on PC12 cells.
ISSN:1738-2203
2468-0834
2234-344X
2468-0842
DOI:10.3839/jksabc.2010.044