Secoiridoid Glycoside from the Flowers of Osmanthus fragrans var. aurantiacus Makino Inhibited the Activity of β-Secretase

Secoiridoid Glycoside from the Flowers of Osmanthus fragrans var. aurantiacus Makino Inhibited the Activity of β-Secretase

One secoiridoid glycoside was isolated from the EtOAc-soluble fraction of flowers of Osmanthus fragrans var. aurantiacus by repeated silica gel, octadecyl silica gel (ODS) and Sephadex LH-20 column chromatographies. It was identified as (8E)-ligstroside based on spectroscopic methods including NMR a...

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Veröffentlicht in:Applied biological chemistry 2010, 53(3), , pp.371-374
Hauptverfasser: Lee, D.G., Kyung Hee University, Yongin, Republic of Korea, Choi, J.S., Ildong Pharmaceutical Co. Ltd., Hwaseong, Republic of Korea, Yeon, S.W., Ildong Pharmaceutical Co. Ltd., Hwaseong, Republic of Korea, Cui, E.J., Kyung Hee University, Yongin, Republic of Korea, Park, H.J., Kyung Hee University, Yongin, Republic of Korea, Yoo, J.S., Ildong Pharmaceutical Co. Ltd., Hwaseong, Republic of Korea, Chung, I.S., Kyung Hee University, Yongin, Republic of Korea, Baek, N.I., Kyung Hee University, Yongin, Republic of Korea
Format: Artikel
Sprache:eng
Schlagworte:
Applied Microbiology
beta-secretase
Biological Techniques
Bioorganic Chemistry
Chemistry
Chemistry and Materials Science
Flowers
Glycosides
Identification methods
IRIDOIDE
IRIDOIDES
IRIDOIDS
NMR
Nuclear magnetic resonance
Osmanthus fragrans
Secretase
Short Communication
Silica
Silica gel
Silicon dioxide
β-Site APP-cleaving enzyme 1
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Beschreibung
Zusammenfassung:One secoiridoid glycoside was isolated from the EtOAc-soluble fraction of flowers of Osmanthus fragrans var. aurantiacus by repeated silica gel, octadecyl silica gel (ODS) and Sephadex LH-20 column chromatographies. It was identified as (8E)-ligstroside based on spectroscopic methods including NMR and MS. This compound has been first isolated from Osmanthus fragrans var. aurantiacus, and showed BACE1 inhibition activity.
ISSN:1738-2203
2468-0834
2234-344X
2468-0842
DOI:10.3839/jksabc.2010.057