A New Xanthene from Desmostachya bipinnata (L.) Stapf Inhibits Signal Transducer and Activator of Transcription 3 (STAT3) and Low-density Lipoprotein-Oxidation

A new xanthene was isolated from the methanolic extract of Desmostachya bipinnnata through repeated silica gel and octadecyl silica gel column chromatographies. Based on spectroscopic data including nuclear magnetic resonance, fast atom bombardment mass spectrometry, and infrared spectroscopy, chemi...

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Veröffentlicht in:	Applied biological chemistry 2011, 54(2), , pp.308-311
Hauptverfasser:	Shrestha, Sabina, Kyung Hee University, Yongin, Republic of Korea, Park, J.H., Kyung Hee University, Yongin, Republic of Korea, Lee, D.Y., Kyung Hee University, Yongin, Republic of Korea, Cho, J.G., Kyung Hee University, Yongin, Republic of Korea, Cui, E.J., Kyung Hee University, Yongin, Republic of Korea, Chung, I.S., Kyung Hee University, Yongin, Republic of Korea, Kwon, B.M., Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea, Cho, M.H., Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea, Jeong, T.S., Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea, Baek, N.I., Kyung Hee University, Yongin, Republic of Korea
Format:	Artikel
Sprache:	eng
Schlagworte:	Applied Microbiology Biological Techniques Bioorganic Chemistry Bombardment CELLS CELLULE CELULAS Chemistry Chemistry and Materials Science Colon Colon cancer Density Desmostatchya bipinnata Infrared spectroscopy low-density lipoprotein-oxidation Mass spectrometry Mass spectroscopy NMR Nuclear magnetic resonance Oxidation Short Communication signal transducer and activator of transcription Silica Silica gel Silicon dioxide Stat3 protein Transcription Xanthene 농학
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Zusammenfassung:	A new xanthene was isolated from the methanolic extract of Desmostachya bipinnnata through repeated silica gel and octadecyl silica gel column chromatographies. Based on spectroscopic data including nuclear magnetic resonance, fast atom bombardment mass spectrometry, and infrared spectroscopy, chemical structure of the compound was determined to be 2,6-dihydroxy-7-methoxy-3H-xanthen-3-one. The compound exhibited inhibitions of signal transducer and activator of transcription 3-dependent luciferase activity in HCT-116 colon cancer cell line with IC∧50 value of 5 μM and low-density lipoprotein-oxidation with IC∧50 value of 27.2 μM.
ISSN:	1738-2203 2468-0834 2234-344X 2468-0842
DOI:	10.3839/jksabc.2011.049