Inhibitory Effect of Citrus Peel Extract on Lipid Accumulation of 3T3-L1 Adipocytes

Inhibitory effects of lipid accumulation by citrus peel extract were evaluated. Citrus peel extract (CPE) (500 ㎍/mL) inhibited lipid and triglyceride accumulation in 3T3-L1 adipocytes by more than 64.5 and 58.7%, respectively and suppressed glycerol-3-phosphate dehydrogenase to the levels of preadip...

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Veröffentlicht in:	Applied biological chemistry 2011, 54(2), , pp.169-176
Hauptverfasser:	Jung, H.K., Bio Industry Center, Daegu Technopark, Daegu, Republic of Korea, Jeong, Y.S., Bio Industry Center, Daegu Technopark, Daegu, Republic of Korea, Park, C.D., Bio Industry Center, Daegu Technopark, Daegu, Republic of Korea, Park, C.H., Bio Industry Center, Daegu Technopark, Daegu, Republic of Korea, Hong, J.H., Catholic University of Daegu, Gyeongsan, Republic of Korea
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation adipocyte Adipocytes Applied Microbiology Barriers Bioactive Meterials Biological Techniques Bioorganic Chemistry Chemistry Chemistry and Materials Science citrus peel extract FLAVONOIDE FLAVONOIDES FLAVONOIDS Gene expression Glycerol Glycerol-3-phosphate Glycerol-3-phosphate dehydrogenase Hesperidin Lipids Lipolysis mRNA perilipin Plant extracts Preadipocytes real time-polymerase chain reaction Triglycerides 농학
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Zusammenfassung:	Inhibitory effects of lipid accumulation by citrus peel extract were evaluated. Citrus peel extract (CPE) (500 ㎍/mL) inhibited lipid and triglyceride accumulation in 3T3-L1 adipocytes by more than 64.5 and 58.7%, respectively and suppressed glycerol-3-phosphate dehydrogenase to the levels of preadipocytes. The expression of perilipin mRNA in 3T3-L1 adipocytes treated with CPE was significantly lower than that in untreated adipocytes (p less than 0.05), with no accompanying increase in lipolysis-related mRNA. Flavonoid compositions of CPE were hesperidin 13.79, narirutin 7, and naringin 262.5 ㎍/g, respectively. These findings suggest CPE may indirectly stimulate lipolysis by inhibiting protection of physical barrier on lipid droplet to hinder lipid accumulation in 3T3-L1 adipocytes.
ISSN:	1738-2203 2468-0834 2234-344X 2468-0842
DOI:	10.3839/jksabc.2011.028