The inhibitory effects of the ethanolic extract of Pimpinella brachycarpa on cytochrome P450 enzymes in humans

Pimpinella brachycarp is a widely distributed vegetable with known antibacterial, antitumor, antioxidant, antithrombotic, and anti-inflammatory effects. In the present study, a cocktail probe assay and LC-MS/MS were used to investigate the modulating effect of the ethanolic extract of P. brachycarp...

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Veröffentlicht in:	Applied biological chemistry 2014, 57(1), , pp.113-116
Hauptverfasser:	O, Heung Chan, Hwang, Jae Yun, Lee, Yoon Ae, Song, Min, Kwon, Oh Kwang, Sim, Ju Hee, Kim, Sunju, Song, Kyung-Sik, Lee, Sangkyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Applied Microbiology Biological Techniques Bioorganic Chemistry Chemistry Chemistry and Materials Science Cytochrome Cytochrome P450 Cytochromes P450 Enzymes Inflammation Microsomes Pimpinella Short Communication 농학
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Beschreibung
Zusammenfassung:	Pimpinella brachycarp is a widely distributed vegetable with known antibacterial, antitumor, antioxidant, antithrombotic, and anti-inflammatory effects. In the present study, a cocktail probe assay and LC-MS/MS were used to investigate the modulating effect of the ethanolic extract of P. brachycarp on CYP enzymes in human liver microsomes. The extract significantly inhibited CYP 1A2, 2B6, and 3A4 by mix-mode inhibition and CYP2C19 and 2D6 by competitive inhibition.
ISSN:	1738-2203 2468-0834 2234-344X 2468-0842
DOI:	10.1007/s13765-013-4206-2