Vater 팽대부 암종에서 Wntz/ β-catenin 신호 경로의 유전자 변화 및 메틸화 연구

Background : Carcinoma of the ampulla of Vater is rare and its pathogenesis is unclear. The role of epigenetic changes in the APC or CDH1, in the Wnt pathway, has not been reported in ampullary carcinomas. Methods : We performed immunohistochemistry on 73 sporadic ampullary carcinomas to identify Wnt-related molecules (APC,β-catenin, E-cadherin, c-erbB2, cyclin D1) and examined mutations in the CTNNB1, loss of heterozygosity of 5q21, and the methylation status of the CpG island of APC and CDH1. Results : Thirteen tumors (17.8%) showed abnormal nuclear localization of -catenin; this was more prominent in the intestinal type than in the pancreaticobiliary type (p=0.01). The loss of APC correlated with the loss of β-catenin or c-erb B2 (p