Expression of p63 and its Isoform, deltaNp63, in Non-Small Cell Lung Carcinoma
Background : Several studies have been conducted on the role of the p63 gene family in nonsmall cell lung carcinoma (NSCLC). Nevertheless, the role of these genes in the development and progression of NSCLC remains controversial. This study was designed to examine the expression and clinicopathologi...
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| Veröffentlicht in: | Journal of pathology and translational medicine 2009, 43(4), , pp.321-328 |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | Background : Several studies have been conducted on the role of the p63 gene family in nonsmall cell lung carcinoma (NSCLC). Nevertheless, the role of these genes in the development and progression of NSCLC remains controversial. This study was designed to examine the expression and clinicopathologic significance of the p63 family in NSCLC. Methods :
Immunohistochemical staining was performed on 92 cases of NSCLC (47 squamous cell carcinomas [SqCCs] and 45 adenocarcinomas [ACs]) using tissue microarray blocks. The results were analyzed and correlated with clinicopathologic data. Results : The expression of deltaNp63 (△Np63) was elevated in SqCC (39/47), but not in AC (2/45; p |
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| ISSN: | 2383-7837 2383-7845 |