Production and Biological Activity of Laidlomycin, Anti-MRSA/VRE Antibiotic from Streptomyces sp. CS684

Culture broth of a streptomycete isolate, Streptomyces sp. CS684 showed antibacterial activity on methicillin resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococci (VRE). Among purified substances from the organism, CSU-1, which is active against MRSA and VRE, is a C∧37H∧62O∧12...

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Veröffentlicht in:	The journal of microbiology 2007, 45(1), , pp.6-10
Hauptverfasser:	Yoo, J.C. (Chosun University, Gwangju, Republic of Korea), Kim, J.H. (Chosun University, Gwangju, Republic of Korea), Ha, J.W. (Chosun University, Gwangju, Republic of Korea), Park, N.S. (Chosun University, Gwangju, Republic of Korea), Sohng, J.K. (Sunmoon University, Asan, Republic of Korea), Lee, J.W. (Catholic University of Pusan, Busan, Republic of Korea), Park, S.C. (Sunchon National University, Sunchon, Republic of Korea), Kim, M.S. (Sunchon National University, Sunchon, Republic of Korea), Seong, C.N. (Sunchon National University, Sunchon, Republic of Korea), E-mail: scnu@scnu.ac.kr
Format:	Artikel
Sprache:	eng
Schlagworte:	ACTINOMYCETALES Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - pharmacology anti-MRSA anti-VRE Drug Resistance, Bacterial Korea laidlomycin Methicillin Resistance Monensin - analogs & derivatives Monensin - biosynthesis Monensin - pharmacology Phylogeny polyether antibiotic Soil Microbiology Staphylococcus aureus Staphylococcus aureus - drug effects Streptomyces Streptomyces - classification Streptomyces - metabolism Streptomyces sp. CS684 Streptomycetes Vancomycin Resistance 생물학
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Zusammenfassung:	Culture broth of a streptomycete isolate, Streptomyces sp. CS684 showed antibacterial activity on methicillin resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococci (VRE). Among purified substances from the organism, CSU-1, which is active against MRSA and VRE, is a C∧37H∧62O∧12Na (M+, 721.3875), and identified as laidlomycin. The anti-MRSA and anti-VRE activity of CSU-1 was stronger than oxacillin and vancomycin. Phylogenetic analysis showed that strain CS684 is very similar to Streptomyces ardus NRRL 2817∨T, whereas the ability of Streptomyces sp. CS684 to produce laidlomycin was shown to be unique.
ISSN:	1225-8873 1976-3794