Antifungal Activity and Mechanism of Fengycin in the Presence and Absence of Commercial Surfactin Against Rhizopus stolonifer

The antifungal activity and mechanism of fengycin in the presence and absence of commercial surfactin against Rhizopus stolonifer were investigated. The MIC (minimal inhibitory concentration) of fengycin without commercial surfactin added was 0.4 mg/ml while the MIC of fengycin with commercial surfa...

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Veröffentlicht in:	The journal of microbiology 2011, 49(1), , pp.146-150
Hauptverfasser:	Tao, Yang, Nanjing Agricultural University, Weigang, Nanjing, P. R. China, Bie, Xiao-mei, Nanjing Agricultural University, Weigang, Nanjing, P. R. China, Lv, Feng-xia, Nanjing Agricultural University, Weigang, Nanjing, P. R. China, Zhao, Hai-zhen, Nanjing Agricultural University, Weigang, Nanjing, P. R. China, Lu, Zhao-xin, Nanjing Agricultural University, Weigang, Nanjing, P. R. China
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Antifungal activity Antifungal agents Antifungal Agents - pharmacology Biomedical and Life Sciences Biosynthetic Pathways - drug effects Cell Membrane - drug effects Cell membranes commercial surfactin DNA - metabolism DNA biosynthesis Drug Interactions fengycin Fungicides Life Sciences lipopeptide Lipopeptides - pharmacology mechanism Microbial Sensitivity Tests Microbiology Minimum inhibitory concentration Organelles - drug effects Peptides Peptides, Cyclic - pharmacology Pesticides Rhizopus - drug effects RHIZOPUS STOLONIFER surfactin 생물학
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Zusammenfassung:	The antifungal activity and mechanism of fengycin in the presence and absence of commercial surfactin against Rhizopus stolonifer were investigated. The MIC (minimal inhibitory concentration) of fengycin without commercial surfactin added was 0.4 mg/ml while the MIC of fengycin with commercial surfactin added was 2.0 mg/ml. Fengycin acted on cell membrane and cellular organs and inhibited DNA synthesis. The antifungal effect of fengycin was reduced after commercial surfactin was added. All these results suggest that the fungal cell membrane may be the primary target of fengycin action and commercial surfactin may reduce the antifungal activity of fengycin.
ISSN:	1225-8873 1976-3794
DOI:	10.1007/s12275-011-0171-9