Involvement of Curli Fimbriae in the Biofilm Formation of Enterobacter cloacae

In this study, we examined the biofilm forming ability, the mRNA expression of curli genes and the morphologies of curli fimbriae and biofilms in clinical isolates of Enterobacter cloacae. The csgBA operon was found in 11 (78.6%) of the 14 isolates. The ability of E. cloacae isolates to form biofilm...

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Veröffentlicht in:	The journal of microbiology 2012, 50(1), , pp.175-178
Hauptverfasser:	Kim, S.M., Division of Magnetic Resonance Research, Korea Basic Science Institute, Cheongwon, Republic of Korea, Lee, H.W., Seoul National University, Seoul, Republic of Korea, Choi, Y.W., Kyungpook National University, Daegu, Republic of Korea, Kim, S.H., Kyungpook National University, Daegu, Republic of Korea, Lee, J.C., Kyungpook National University, Daegu, Republic of Korea, Lee, Y.C., Kyungpook National University, Daegu, Republic of Korea, Seol, S.Y., Kyungpook National University, Daegu, Republic of Korea, Cho, D.T., Kyungpook National University, Daegu, Republic of Korea, Kim, J.M., Kyungpook National University, Daegu, Republic of Korea
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Adhesion Bacterial Proteins - genetics Bacterial Proteins - metabolism biofilm Biofilms Biofilms - growth & development Biomedical and Life Sciences curli ENTEROBACTER CLOACAE Enterobacter cloacae - growth & development Enterobacter cloacae - physiology Extracellular matrix Fibers Fimbriae, Bacterial - physiology Gene Expression Profiling Genes Humans Life Sciences Microbiology Nosocomial infections RNA, Messenger - biosynthesis RNA, Messenger - genetics Veterinary medicine 생물학
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Zusammenfassung:	In this study, we examined the biofilm forming ability, the mRNA expression of curli genes and the morphologies of curli fimbriae and biofilms in clinical isolates of Enterobacter cloacae. The csgBA operon was found in 11 (78.6%) of the 14 isolates. The ability of E. cloacae isolates to form biofilms was significantly correlated with the mRNA expression level of the csgA and csgD genes. The curli protein fimbriae appeared as tangled fibers and the curli-proficient strain formed mature biofilms. Our data suggest that the expression of the curli fimbriae play an important role in biofilm formation in E. cloacae.
ISSN:	1225-8873 1976-3794
DOI:	10.1007/s12275-012-2044-2