2-(Pyrazol-1-yl)quinoxaline류 및 2,3-Di(pyrazol-1-yl)quinoxaline류의 합성

The reaction of 3,6-dichloro-2-(3,5-dimethylpyrazol-1-yl)quinoxaline(8) or 6-chloro-3-hydrazino-2-(3,5-dimethylpyrazol-1-yl)quinoxaline(9) with substituted anilines, sulfa drugs and heteroacyl chlorides gave 2-(pyrazol-1-yl)quinoxalines(10-12). The reaction of compound 9 with alkyl (ethoxymeth-ylene) cyanoacetates resulted in the intramolecular cyclization to give 2,3-di(pyrazol-1-yl)quinoxalines(13). 3,6-Dichloro-2-(3,5-dimethylpyrazol-1-yl)quinoxaline(8)또는 6-chloro-3-hydrazino-2-(3,5-dimethylpyrazol-1-yl)quinoxaline(9)을 치환 아닐린류, 슬파제 및 heteroacyl chloride류와 반응시켜 2-(pyrazol-1-yl)quinoxaline류(10-12)를 합성하였다. 그리고 화합물 9를 alkyl (ethoxymethylene)cyanoacetate류와 반응시켜 분자내 고리화반응에 의하여 2,3-di(pyrazol-1-yl)quinoxaline류(13)를 합성하였다.