Design and Synthesis of Resin-Conjugated Tamiflu Analogs for Affinity Chromatography

Design and Synthesis of Resin-Conjugated Tamiflu Analogs for Affinity Chromatography

Two types of resin-conjugated Tamiflu analogs were synthesized by modifying our original synthetic route of oseltamivir phosphate (Tamiflu). The prepared resins bound to influenza virus neuraminidase, the main target of Tamiflu. The resins will be useful for isolating and identifying presumed endoge...

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Veröffentlicht in:Bulletin of the Korean Chemical Society 2010, 31(3), , pp.588-594
Hauptverfasser: Kimura, Yasuaki, Yamatsugu, Kenzo, Kanai, Motomu, Echigo, Noriko, Kuzuhara, Takashi, Shibasaki, Masakatsu
Format: Artikel
Sprache:eng
Schlagworte:
화학
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Zusammenfassung:Two types of resin-conjugated Tamiflu analogs were synthesized by modifying our original synthetic route of oseltamivir phosphate (Tamiflu). The prepared resins bound to influenza virus neuraminidase, the main target of Tamiflu. The resins will be useful for isolating and identifying presumed endogenous vertebrate proteins that interact with Tamiflu, which might relate to the rarely observed abnormal behavior exhibited by some influenza patients treated with Tamiflu KCI Citation Count: 2
ISSN:0253-2964
1229-5949
DOI:10.5012/bkcs.2010.31.03.588