Inhibitory Effect of 4-Aryl 2-Substituted Aniline-thiazole Analogs on Growth of Human Prostate Cancer LNCap Cells

Inhibitory Effect of 4-Aryl 2-Substituted Aniline-thiazole Analogs on Growth of Human Prostate Cancer LNCap Cells

Androgen receptor (AR) is ligand-inducible nuclear hormone receptor which has been focused on key molecular target in growth and progression of prostate cancer. We synthesized a series of 4-aryl 2-substituted aniline-thiazole analogs and evaluated their anti-cancer activity in AR-dependent human pro...

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Veröffentlicht in:Bulletin of the Korean Chemical Society 2012, 33(1), , pp.111-114
Hauptverfasser: Baek, Seung-Hwa, Kim, Nak-Jeong, Kim, Seong-Hwan, Park, Kwang-Hwa, Jeong, Kyung-Chae, Park, Bae-Keun, Kang, Nam-Sook
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Sprache:eng
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화학
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Zusammenfassung:Androgen receptor (AR) is ligand-inducible nuclear hormone receptor which has been focused on key molecular target in growth and progression of prostate cancer. We synthesized a series of 4-aryl 2-substituted aniline-thiazole analogs and evaluated their anti-cancer activity in AR-dependent human prostate cancer LNCap cells. Among them, the compound 6 inhibited the tumor growth in LNCap-inoculated xenograft model. KCI Citation Count: 2
ISSN:0253-2964
1229-5949
DOI:10.5012/bkcs.2012.33.1.111