Thieny/Furanyl-hydroxyphenylpropenones as Inhibitors of LPS-induced ROS and NO Production in RAW 264.7 Macrophages, and Their Structure-Activity Relationship Study

Twelve thienyl/furanyl-hydroxyphenylpropenones were systematically designed and synthesized, and evaluated for their inhibitory effect on LPS-induced ROS and NO production in RAW 264.7 macrophages. Compound 11 displayed the most significant inhibitory activity of LPS-induced ROS and NO production in...

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Veröffentlicht in:Bulletin of the Korean Chemical Society 2014, 35(8), , pp.2481-2486
Hauptverfasser: Kadayat, Tara Man, Kim, Mi Jin, Nam, Tae-Gyu, Park, Pil-Hoon, Lee, Eung-Seok
Format: Artikel
Sprache:eng
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Zusammenfassung:Twelve thienyl/furanyl-hydroxyphenylpropenones were systematically designed and synthesized, and evaluated for their inhibitory effect on LPS-induced ROS and NO production in RAW 264.7 macrophages. Compound 11 displayed the most significant inhibitory activity of LPS-induced ROS and NO production in RAW 264.7 macrophages. Structure-activity relationship study indicated that para-hydroxyphenyl moiety plays an important role for inhibitory activities on both LPS-induced ROS and NO production as well as 3- thienyl moiety on molecule. KCI Citation Count: 8
ISSN:0253-2964
1229-5949
DOI:10.5012/bkcs.2014.35.8.2481