PLA-POE-PLA 블록공중합체 분산액에 의한 생체적합성의 평가 및 특성

PLLA-POE-PLLA block copolymers were prepared using PLLA and POE with different compositions. Copolymers were obtained in high yield and the polydispersity of the copolymers was very narrow. A dispersed solution of 0.1 g/mL of PLLA-POE-PLLA copolymer was mixed with a dispersed solution of 0.1 g/mL of PDLA-POE-PDLA copolymer. Gel formation was observed from the mixed product obtained at the human body temperature of $37^{\circ}C$. The mixed product comprising PDLA-POE-PDLA and PLLA-POE-PLLA was found to have higher cloud points than that of PLLA-POE-PLLA copolymer. The cloud points decreased with increasing the concentration of the mixed copolymer dispersed solution. 조성비가 서로 다른 각종의 PLLA-POE-PLLA와 PDLA-POE-PDLA블록공중합체의 합성을 실시하여 모든 공중합체를 고수율이며 다분산도가 현저하게 작은 생성물을 얻었으며, 그 결과 체온 부근인 $37^{\circ}C$에서는 0.1 g/mL PLLA-POE-PLLA 분산액과 0.1 g/mL PDLA-POE-PDLA의 혼합분산액에서 겔의 형성이 관찰되었다. 또한 PLLA-POE-PLLA분산액과 비교하여 PLLA-POE-PLLA분산액과 PDLA-POE-PDLA분산액을 혼합한 분산액의 흐림점이 높아지는 것을 확인하였으며 고농도일수록 흐림점이 낮아지는 현상도 확인되었다.