Hematopoietic effect of Bacillus subtilis-fermented antler extract on phenylhydrazine-induced hemolytic anemia in Sprague-Dawley rats

This study examined the effect of fermentation on the ability of antler to act as a stimulator of hematopoietic activity. Hemolytic anemia was induced by phenylhydrazine (PHZ) in female Sprague-Dawley rats. The vehicle or antler extract (nonfermented or fermented) mixed in drinking water was adminis...

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Veröffentlicht in:	Journal of medicinal food 2012, 15(9), , pp.774-780
Hauptverfasser:	Lee, Sang Hun, Suh, Hyung Joo, Lee, Hyun-Sun, Park, Yooheon, Park, Jang-Woo, Jung, Eun Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia, Hemolytic - blood Anemia, Hemolytic - diet therapy Animals Antlers - chemistry Bacillus subtilis - metabolism Deer Erythrocyte Count Erythropoietin - blood Female Fermentation Food, Preserved - adverse effects Food, Preserved - microbiology Hematinics - adverse effects Hematinics - metabolism Hematinics - therapeutic use Hematopoiesis Hemoglobins - analysis Humans Male Materia Medica - adverse effects Materia Medica - metabolism Materia Medica - therapeutic use Medicine, East Asian Traditional Osmotic Fragility Phenylhydrazines Random Allocation Rats Rats, Sprague-Dawley 식품과학
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Zusammenfassung:	This study examined the effect of fermentation on the ability of antler to act as a stimulator of hematopoietic activity. Hemolytic anemia was induced by phenylhydrazine (PHZ) in female Sprague-Dawley rats. The vehicle or antler extract (nonfermented or fermented) mixed in drinking water was administered from Days 2 to 15 after PHZ injection. On Day 15, red blood cell counts in the fermented antler group (6.33×10⁶/μL) were significantly higher than those in the nonfermented antler group (5.90×10⁶/μL) (P
ISSN:	1096-620X 1557-7600
DOI:	10.1089/jmf.2012.2264