Effects of Fucoidan on Neuronal Cell Proliferation: Association with NO Production through the iNOS Pathway

Fucoidan, that is high-molecular-weight sulfated polysaccharides extracted from brown seaweeds has been shown to elicit various biological activities. Here, we investigated the effects of fucoidan on cell proliferation and nitric oxide (NO) production in neuronal blastoma cell (SH-SY5Y). In the present study, we demonstrated that fucoidan treatment resulted in increase of cell proliferation and NO production. When cells were treated with amyloid-β (Aβ) in the absence or presence of fucoidan, fucoidan recovered the cell viability decreased by Aβ peptides.