Iron Enhances NGF-induced Neurite Outgrowth in PC12 Cells

Iron Enhances NGF-induced Neurite Outgrowth in PC12 Cells

Rat pheochromocytoma 12 (PC12) cells undergo neuronal differentiation in response to nerve growth factor (NGF). NGF-induced differentiation involves a number of protein kinase, including extracellular signal -regulated kinase (ERK). We studied the effect of iron on neuronal differentiation, using as...

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Veröffentlicht in:Molecules and cells 2004, 17(2), , pp.340-346
Hauptverfasser: Yoo, Y.E, Hong, J.H, Hur, K.C, Oh, E.S, Chung, J.M. (Ewha Womans University, Seoul, Republic of Korea)
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Differentiation - physiology
GROWTH
Iron - metabolism
MAP Kinase Signaling System - physiology
Mitogen-Activated Protein Kinases - metabolism
Nerve Growth Factor - metabolism
Neurites - metabolism
PC12 Cells - metabolism
Rats
생물학
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Zusammenfassung:Rat pheochromocytoma 12 (PC12) cells undergo neuronal differentiation in response to nerve growth factor (NGF). NGF-induced differentiation involves a number of protein kinase, including extracellular signal -regulated kinase (ERK). We studied the effect of iron on neuronal differentiation, using as model the neurite outgrowth of PC12 cells triggered by NGF when the cells are plated on collagen-coated dishes in medium containing 1 serum.
ISSN:1016-8478
0219-1032
DOI:10.1016/s1016-8478(23)13048-2