In vitro Selection of Specific RNA Aptamers for the NFAT DNA Binding Domain

Nuclear factor of activated T cells (NFAT) plays a central role in the immune response, and the immunosuppressive drugs, cyclosporin A and FK-506, have been developed to inhibit it.

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Bibliographische Detailangaben
Veröffentlicht in:	Molecules and cells 2004, 18(1), , pp.17-23
Hauptverfasser:	Cho, J.S, Lee, Y.J, Jeong, S.J, Lee, S.W. (Dankook University, Seoul, Republic of Korea), Shin, K.S. (Genoprot Inc., Seoul, Republic of Korea), Park, J.C. (Hankuk University of Foreign Studies, Yongin, Republic of Korea)
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence DNA DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Humans Molecular Sequence Data NFATC Transcription Factors Nuclear Proteins - genetics Nuclear Proteins - metabolism Nucleic Acid Conformation Protein Binding Protein Structure, Tertiary Recombinant Proteins - genetics Recombinant Proteins - metabolism RNA - chemistry RNA - metabolism Transcription Factors - genetics Transcription Factors - metabolism 생물학
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Beschreibung
Zusammenfassung:	Nuclear factor of activated T cells (NFAT) plays a central role in the immune response, and the immunosuppressive drugs, cyclosporin A and FK-506, have been developed to inhibit it.
ISSN:	1016-8478 0219-1032
DOI:	10.1016/s1016-8478(23)13076-7