The Putative Transcriptional Activator MSN1 Promotes Chromium Accumulation in Saccharomyces cerevisiae

Yeast is a good system for studying molecular mechanisms of metal tolerance. Using a mini-Tn mutagenized yeast pool, we isolated a chromate-tolerant mutant, CrT9, that displayed metal-specific tolerance since it was only tolerant to Cr(VI), not to Cr(Ñ¦), Cd, As, or Fe. The Cr-tolerance of CrT9 appe...

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Veröffentlicht in:	Molecules and cells 2003, 16(3), , pp.291-296
Hauptverfasser:	Chang, K.S, Won, J.I, Lee, M.R, Lee, C.E, Hwang, S.B. (Sejong University, Seoul, Republic of Korea), Hwang Kim, K.M. (Ajou University, Suwon, Republic of Korea), Park, K.Y. (Sunchon National University, Sunchon, Republic of Korea), Kim, S.K. (Chung-Ang University, Seoul, Republic of Korea), Lee, J.S. (Ewha Womans University, Seoul, Republic of Korea)
Format:	Artikel
Sprache:	eng
Schlagworte:	CHROMIUM Chromium - metabolism DNA Transposable Elements - physiology DNA-Binding Proteins - metabolism Immediate-Early Proteins Mutation Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins Transcription Factors Transcriptional Activation - physiology 생물학
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Zusammenfassung:	Yeast is a good system for studying molecular mechanisms of metal tolerance. Using a mini-Tn mutagenized yeast pool, we isolated a chromate-tolerant mutant, CrT9, that displayed metal-specific tolerance since it was only tolerant to Cr(VI), not to Cr(Ñ¦), Cd, As, or Fe. The Cr-tolerance of CrT9 appeared to be due to reduced Cr accumulation as it accumulated only 56 as much as WT (Y800).
ISSN:	1016-8478 0219-1032
DOI:	10.1016/S1016-8478(23)13803-9