사시 수술을 위한 Propofol 목표농도주입과 Fentanyl 사용시 진정깊이가 회복에 미치는 영향

Background: An immediate examination of ocular movement is required during strabismus surgery. The aim of this study was to determine the effect of the level of sedation on the recovery of patients undergoing a target controlled propofol infusion with a bolus of fentanyl for strabismus surgery. Methods: Twenty-one outpatients scheduled to undergo strabismus surgery were assigned randomly to one of two groups. In both groups, sedation was induced with a bolus of fentanyl 1μg/kg intravenously followed by an infusion of propofol with a target concentration of 1.0μg/ml. The target concentration was increased or decreased by 0.1 μg/ml steps until the patient reached and maintained the observer's assessment of alertness/sedation (OAA/S) scale score of 3 (group A) or 4 (group B). The supplemental analgesics consisted of fentanyl 25－50μg bolus injection. The target concentration of propofol, the total dose of fentanyl, delayed awakening, and recovery time were recorded. Results: The mean target concentration of propofol (mean ± SD) in group A (1.8 ± 0.4μg/ml) was significantly higher than that of group B (1.3 ± 0.4μg/ml) (P ＜ 0.05). There were no significant differences in the total dose of fentanyl, delayed awakening and recovery time between the two groups. There was an an increasing trend in the recovery time with the total dose per kilogram of body weight of fentanyl (Spearman's correlation coefficient, r = 0.384, P = 0.086). Conclusions: The levels of sedation did not affect the recovery time in patients during target propofol infusion with a bolus of fentanyl. However, the addition of fentanyl tended to prolong the recovery time. KCI Citation Count: 0