Identification and Epigenetic Analysis of a Maternally Imprinted Gene Qpct

Most imprinted genes are concerned with embryonic development, especially placental development. Here, we identified a placenta-specific imprinted gene Qpct. Our results show that Qpct is widely expressed during early embryonic development and can be detected in the telecephalon, midbrain, and rhomb...

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Veröffentlicht in:	Molecules and cells 2015, 38(10), , pp.859-865
Hauptverfasser:	Guo, J., Harbin Institute of Technology, Heilongjiang, China, He, H., Harbin Institute of Technology, Heilongjiang, China, Liu, Q., Harbin Institute of Technology, Heilongjiang, China, Zhang, F., Harbin Institute of Technology, Heilongjiang, China, Lv, J., Harbin Institute of Technology, Heilongjiang, China, Zeng, T., Harbin Institute of Technology, Heilongjiang, China, Gu, N., Harbin Institute of Technology, Heilongjiang, China, Wu, Q., Harbin Institute of Technology, Heilongjiang, China
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoacyltransferases - genetics Animals Chromatin Immunoprecipitation DNA Methylation Embryonic Development - genetics expression patterns,H3K4me3,imprinted gene,Qpct Female Gene Expression Regulation, Developmental Genomic Imprinting Histones - genetics Histones - metabolism Liver - embryology Liver - metabolism Lung - embryology Lung - metabolism Male Mesencephalon - embryology Mesencephalon - metabolism Mice Mice, Inbred C57BL Mothers PLACENTA Placenta - metabolism Placentation - genetics Pregnancy Rhombencephalon - embryology Rhombencephalon - metabolism Telencephalon - embryology Telencephalon - metabolism 생물학
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Zusammenfassung:	Most imprinted genes are concerned with embryonic development, especially placental development. Here, we identified a placenta-specific imprinted gene Qpct. Our results show that Qpct is widely expressed during early embryonic development and can be detected in the telecephalon, midbrain, and rhombencephalon at E9.5 - E11.5. Moreover, Qpct is strikingly expressed in the brain, lung and liver in E15.5. Expression signals for Qpct achieved a peak at E15.5 during placental development and were only detected in the labyrinth layer in E15.5 placenta. ChIP assay results suggest that the modification of histone H3K4me3 can result in maternal activating of Qpct.
ISSN:	1016-8478 0219-1032
DOI:	10.14348/molcells.2015.0098