Risk factors for BiPAP failure as an initial management approach in moderate to late preterm infants with respiratory distress

Question: Which factors can predict BiPAP failure as the initial management approach for moderate to late preterm infants with respiratory distress? Finding: RDS aggravation and increased oxygen and frequency requirements during BiPAP support were associated with BiPAP failure. Meaning: Early changes to invasive ventilator care should be considered for moderate to late preterm infants showing RDS aggravation and increased oxygen and frequency requirements during BiPAP support.