쥐의 신경병증성 통증 모델에서 아미카신의 진통효과

Background: Recently, aminoglycoside antibiotics such as gentamicin, neomycin and amikacin have been known to have antinociceptive effects on several pain models in rats and mice, in addition to their antibacterial activities. However, there has been no report concerning aminoglycoside`s antinocicep...

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Veröffentlicht in:The Korean journal of pain 2002, 15(1), , pp.43-47
Hauptverfasser: 윤태균, Tae Gyoon Yoon, 김현정, Hyun Jeong Kim, 염광원, Kwang Won Yum
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Sprache:kor
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Zusammenfassung:Background: Recently, aminoglycoside antibiotics such as gentamicin, neomycin and amikacin have been known to have antinociceptive effects on several pain models in rats and mice, in addition to their antibacterial activities. However, there has been no report concerning aminoglycoside`s antinociceptive effects on neuropathic pain. The present study was undertaken to assess the antinociceptive action of amikacin and also investigate a possible antinociceptive mechanisms through the use of antagonists in an neuropathic pain models in rats. Methods: Rats were prepared with tight ligation at the left 5^th and 6^th lumbar spinal nerves (according to Kim and Chung`s neuropathic pain model). The antinociceptive effects of amikacin (1, 10, and 100mg/kg i.p.) in rats with neuropathic pain were assessed. In addition, after co-administration of naloxone(1 mg/kg i..p.) with 10 mg/kg of amikacin, the responses to mechanical stimulus were measured over two hours. Results: The antinociceptive effects shown by amikacin on neuropathic pain were significant (P <0.05), but were inhibited by co-administred nalxone in rats with mechanical allodynia. Conclusions: Amikacin showed significant antinociceptive effects in rats with neuropathic pain against mechanical allodynia. The antinociceptive effect on the mechanical stimuli was mediated through the opioid receptor.
ISSN:2005-9159
2093-0569