Gender difference in colorectal cancer indicators for exercise interventions: the National Health Insurance Sharing Service-Derived Big Data Analysis

We aimed to examine various characterized features and effects of gender-associated different parameters including exercise on the prev-alence of colorectal cancer by using data from the National Health In-surance Sharing Service Database (NHISS DB). Data from NHISS were collected on Koreans aged from 40 to 85 years and were subject-ed to thematic analysis. The colorectal cancer codes (C19, C20, D011, and D012) from Korean Standard Classification of Disease and Causes of Death selected a target study group, and t-test and logistic regres-sion were used. As results, the age was higher for men who had col-orectal cancer than the noncancer group; however, high and low blood pres-sure, hemoglobin, and age had lower values for the cancer group com-pared to their counterparts in women. Only total cholesterol in men and waist size in women between cancer and noncancer groups were shown to have significant differences. Serum glutamic pyruvic trans-aminase and alanine aminotransaminase (SGPT_ALT) showed signifi-cant differences for both sexes. In exercise-related parameter, the re-sponse number 2 (1–2 times/wk, 0.535 for odd ratio) in women and re-sponse number 3 (3–4 times/wk, 0.466 for odd ratio) in men were asso-ciated with a reduced incidence of colon cancer. There was a dif-fer-ence in parameters in colorectal cancer patients over 40 years old for both sexes, but not in SGPT_ALT. Regular physical activity might be one of strong factors affecting or predicting colorectal cancer incidence.