Analysis of Major Factors Affecting False Positive Results in Neonatal Screening Test within 3 Days after Birth

Objective: We examined the factors affecting the false positive results in the accidental neonatal screening test (NST) within 3 days after birth and tried to find out the most relevant factors. Methods: From January 2011 to December 2016, we reviewed the electronic medical records of 142 patients with a gestational age of 34 weeks or more who had false positives at the first NST. NST was performed by tandem mass spectrometry. We collected information on gestational age, birth weight, delivery method, Apgar score at the time of birth. Postnatal exam time, body weight, feeding volume and parenteral nutrition, antibiotics, and steroid administration were also investigated at the time of NST. Results: In the first NST, there were 102 cases of congenital adrenal hyperplasia, 27 cases of congenital hypothyroidism, nine cases of galactosemia and one case of homocystinuria. Gender, birth weight, and delivery method were statistically significant (P