Ureaplasma urealyticum과 Staphylococcus aureus에 감작된 마우스 복강 대식세포의 탐식능의 변화

Several investigators have reported that mycoplasmas might activate macrophages, but some other investigators do not agree with this view. Furthermore, the interaction between ureaplasmas and macrophages has not been studied previously. The phagocytic activies of mice peritoneal macrophages activated with Ureaplasma urealyticum(U. urealyticum) or Staphylococcus aureus(S. aureus) have been compared by calculating Candida albicans(C. albicans) uptake. At same time, hematological changes of peripheral white blood cells in U. urealyticum or S. aureus infected mice were examined. The results are : 1. The phagocytic activities of peritoneal macrophages infected 1 - 4 times with U. urealyticum or S. aureus were augumented for 72 hours. But, after 96 hours, the phagocytic activities of U. urealyticum activated macrophages were decreased, and the phagocytic activities of S. aureus activated macrophages were increased. 2. The number of peritoneal cells infected 1 - 4 times with U. urealyticum or S. aureus were increased after 24 hours, but continuously decreased during 48 - 96 hours. 3. The phagocytic activities of peritoneal macrophages, against C. albicans, activated by U. urealyticum or S. aureus showed the highest activity ini 2 - 3 hours. 4. The number of polymorphonuclear leukocytes in peripheral blood of U. urealyticum or S. aureus infected mice were increased durinig 24 - 72 hours or 24 - 96 hours, respectively. 5. The number of white blood cells in peripheral blood infected by U. urealyticum were variable during 24 - 96 hours. However, the number of white blood cells in peripheral blood by S. aureus were continuously increased during 24 - 96 hours. KCI Citation Count: 0