DNA hypermethylation of tumor-related genes in gastric carcinoma

The hypermethylation of the CpG islands is a common mechanism for the inactivation of tumor-related genes. In the present study, we analyzed the methylation status of genes for cell repair such as hMLH1, MGMT, and GSTP1, and a gastric cancer-specifically methylated DNA fragment, MINT 25 in gastric c...

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Veröffentlicht in:	Journal of Korean medical science 2005, 20(2), , pp.236-241
Hauptverfasser:	Hong, Su Hyung, Kim, Ho Gak, Chung, Woon Bok, Kim, Eun Young, Lee, Jong Young, Yoon, Sang Mo, Kwon, Joong Goo, Sohn, Yoon Kyung, Kwak, Eun Kyung, Kim, Jung Wan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adult Aged Carrier Proteins DNA Methylation Female Glutathione S-Transferase pi Glutathione Transferase - genetics Humans Isoenzymes - genetics Male Middle Aged MutL Protein Homolog 1 Neoplasm Proteins - genetics Nuclear Proteins - genetics O-Methylguanine-DNA Methyltransferase - genetics Original Promoter Regions, Genetic Stomach Neoplasms - genetics 의학일반
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Zusammenfassung:	The hypermethylation of the CpG islands is a common mechanism for the inactivation of tumor-related genes. In the present study, we analyzed the methylation status of genes for cell repair such as hMLH1, MGMT, and GSTP1, and a gastric cancer-specifically methylated DNA fragment, MINT 25 in gastric cancer cases and control groups. The study population consisted of 100 gastric cancer patients (50 distal and 50 proximal carcinomas), and 238 healthy controls. All genes showed more frequent hypermethylation in the cases than in the control group (p
ISSN:	1011-8934 1598-6357
DOI:	10.3346/jkms.2005.20.2.236