Use of aripiprazole in clozapine induced enuresis: report of two cases

This report describes the efficacy of combined use of aripiprazole in the treatment of a patient with clozapine induced enuresis. Aripiprazole acts as a potential dopamine partial agonist and the dopamine blockade in the basal ganglia might be one of the causes of urinary incontinence and enuresis....

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Veröffentlicht in:	Journal of Korean medical science 2010, 25(2), 135, pp.333-335
Hauptverfasser:	Lee, Myung-Ji, Kim, Chul-Eung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antipsychotic Agents - adverse effects Aripiprazole Case Report Clozapine - adverse effects Dopamine - metabolism Dopamine Agonists - therapeutic use Drug Therapy, Combination Enuresis - chemically induced Enuresis - drug therapy Humans Male Middle Aged Piperazines - therapeutic use Quinolones - therapeutic use Schizophrenia, Paranoid - drug therapy 의학일반
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Zusammenfassung:	This report describes the efficacy of combined use of aripiprazole in the treatment of a patient with clozapine induced enuresis. Aripiprazole acts as a potential dopamine partial agonist and the dopamine blockade in the basal ganglia might be one of the causes of urinary incontinence and enuresis. We speculate that aripiprazole functioned as a D2 agonist in hypodopaminergic state of basal ganglia caused by clozapine and maintained dopamine level that would improve enuresis ultimately.
ISSN:	1011-8934 1598-6357
DOI:	10.3346/jkms.2010.25.2.333