정상 신기능을 가진 제2형 당뇨병 환자에서 혈중 시스타틴-C 농도와 동맥경화도의 관계

Objective: Several studies showed that increased arterial stiffness is an independent risk factor for cardiovascular disease. Pulse wave velocity (PWV) is known as a marker for large vessel stiffness. Recent studies show that serum cystatin C is associated with PWV and may predict future cardiovascular events, even in subjects with normal renal function. However, there have been few studies for the relationship between cystatin C and arterial stiffness in patients with type 2 diabetes (T2DM). In this study, we investigated the relationship between serum cystatin C and branchial-ankle PWV in T2DM patients with normal renal function. Methods: Patients with urinary albumin/creatinine ratio (ACR) higher than 300 μg albumin/mg creatinine, estimated glomerular filtration rate (eGFR) less than 60 mL/min were excluded. A total of 88 patients (47 male/41 female; age, 59±2 years; ACR, 33±5 μg/mg) were included. Doppler-derived aortic PWV and serum cystatin C were measured. Results: Cystatin C is significantly related to age (r=0.51, P