생체 외에서 시행한 정량적 자기공명영상, 단일 에너지 정량적 전산화단층촬영술, 그리고 이중엑스선 골밀도측정기 사이의 연관성

This study was performed to examine the correlation among quantitative magnetic resonance (QMR), single energy quantitative computed tomography (SE-QCT), and dual energy X-ray absorptiometry (DXA), and to examine the relation with bone mineral density (BMD) through in vitro experiment with pig lumbar vertebrae. The correlation among 1/T2 of QMR, SE-QCT, and DXA was investigated by measuring the pig lumbar vertebrae BMD five times each method. It was examined whether there is a significant difference in the values of 1/T2, SE-QCT, and DXA measured by changing the height (11cm, 20cm, 29cm) of water in water bath in order to make the soft tissues different in quantity. The lumbar vertebrae were placed in 0.1N sodium hydroxide (NaOH) solution for 24 hours to remove the residual soft tissue. Each values of SE-QCT before and after removal of the soft tissue were compared. Real BMD, measured after burning only the body of lumbar vertebrae for 3 hours at 1200℃, was compared to BMD with three methods. Based on the correlation analysis of 1/T2 and SE-QCT (correlation coefficient, r=-0.729 to 0.737), 1/T2 and DXA (r=-0.709 to 0.929), and SE-QCT and DXA (r=-0.878 to 0.862) after measuring BMD within the water bath, no significant correlation was observed among three methods. Also, there was no correlation between 1/T2 and SE-QCT (r=-0.587 to 0.447) measured in the outside of water bath. SE-QCT (P=0.094) and 1/T2 (P=0.012 to 0.094) measured in the inside and the outside, respectively, of the water bath were significantly different. When the height of water in the water bath was different, the change value of the BMD showed a significant difference in 1/T2 (P=0.012 to 0.403) and SE-QCT (P=0.012 to 0.527), but not in DXA (P=0.012). The values of SE-QCT measured before and after placing lumbar vertebrae in 0.1N NaHOH for 24 hours were not significantly different (P=0.3177). The BMD and 1/T2 measured after burning showed the similar changing aspect (P=0.028 to 0.106), however SE-QCT and DXA showed the different changing aspect (P