Potent anti-adhesion agent using a drug-eluting visible-light curable hyaluronic acid derivative

[Display omitted] Post-operative adhesion is a very serious complication in the clinical field, frequently occurring after surgery. In severe cases, reoperation may be required. In this study, a visible light-curable furfuryl hyaluronic acid derivative was prepared and combined with ibuprofen for anti-adhesion and anti-inflammatory applications. A furfuryl isocyanate moiety was introduced in hyaluronic acid affording furfuryl hyaluronic acid (F-HA). The anti-adhesion and anti-inflammatory effects of F-HA were examined in chickens at 2, 4, and 8 weeks postoperation. It was concluded that F-HA combined with ibuprofen is a suitable anti-adhesion and anti-inflammation agent.