WHODAS 2.0으로 평가한 만성 조현병 환자의 기능 장애와 관련 요인

Objectives This study examined the functional disabilities of patients with chronic schizophrenia using WHO Disability Assessment Schedule 2.0 (WHODAS 2.0) and its related factors. Methods The subjects consisted of 86 patients with schizophrenia with more than 10 years’ duration of illness and 40 healthy volunteers. The functional disabilities and psychopathology were evaluated using the WHODAS 2.0 and 18-items Brief Psychiatric Rating Scale (BPRS-18), respectively. This study analyzed the six sub-domains (‘cognition’, ‘mobility’, ‘self-care’, ‘getting along’, ‘life activities’, and ‘participation’) of WHODAS 2.0 and the four sub-scales (‘positive symptoms’, ‘negative symptoms’, ‘affect’, and ‘resistance’) of BPRS-18. Results Patients with chronic schizophrenia experienced severe functional disabilities across all six sub-domains of WHODAS 2.0 compared to healthy people. Hierarchical regression showed that ‘negative symptoms’ explained the disabilities in the WHODAS 2.0 sub-domains of ‘cognition’ (p