Association of glutathione S-transferase M1 and T1 null/present polymorphism with physical performance in the Korean population
Human physical performance is a highly complex phenotype that is influenced by various factors. In particular, genetic factors related to muscle fiber type, bone density, muscle performance, and metabolic processes are known to contribute in varying degrees to athlete status and physical performance...
Gespeichert in:
Veröffentlicht in: | Genes & genomics 2019, 41(1), , pp.71-78 |
---|---|
Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Human physical performance is a highly complex phenotype that is influenced by various factors. In particular, genetic factors related to muscle fiber type, bone density, muscle performance, and metabolic processes are known to contribute in varying degrees to athlete status and physical performance in various ethnic groups. To investigate the relationship between these genetic factors and physical performances, we genotyped five genetic polymorphisms (
ACE
Ins/Del,
ACTN3
R577X,
ER-α
C/T,
GSTM1
null/present, and
GSTT1
null/present) in 111 Korean athletes and 145 controls. We examined genotype and allele frequency differences between athletes and control groups, along with the odds ratios, using Chi square. One-way analysis of variance (ANOVA) was used to test the significance of differences in continuous variables between the multiple genetic polymorphisms and physical performance test results. The
GSTM1
polymorphism exhibited a highly significant association in athletes (
p
= 0.017). Combined analysis of
GSTM1
and
GSTT1
also revealed significant differences between athletes and controls (
p
|
---|---|
ISSN: | 1976-9571 2092-9293 |
DOI: | 10.1007/s13258-018-0737-6 |