In vitro and in vivo inhibition of Helicobacter pylori by Lactobacilllus paracasei HP7

The efficacy of standard therapeutic strategies for ( ) infection is decreasing over time due to the emergence of drug-resistant strains. As an alternative, the present study investigated the capacity of ( ) HP7, isolated from kimchi, to inhibit growth. The effects of HP7 on adhesion and -induced inflammation were examined in AGS human gastric adenocarcinoma epithelial cells and a mouse model of SS1 infection. HP7 reduced adhesion to AGS cells and suppressed the inflammatory response in infected cells by downregulating interleukin-8. colonization in the stomach of C57BL/6 mice was demonstrated by rapid urease test, and results showed significant decrease in mice post-treated with HP7. Additionally, HP7 decreased gastric inflammation and epithelial lesions in the stomach of -infected mice. These results demonstrate that HP7 treatment can inhibit growth and is thus a promising treatment for patients with gastric symptoms such as gastritis that are caused by infection.