Acronyculatin P, A New Isoprenylated Acetophenone from the Stem Bark of Acronychia pedunculata

Acronyculatin P, A New Isoprenylated Acetophenone from the Stem Bark of Acronychia pedunculata

A new isoprenylated acetophenone, acronyculatin P (1) as well as two known compounds, 3',5'-diisoprenyl-2',4'-dihydroxy-6'-methoxyphenylethanone (2) and 3'-isoprenyl-2',4',6'-trihydroxyphenylethanone (3) were isolated from the stem bark of Acronychia pedu...

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Veröffentlicht in:Natural product sciences 2018, 24(4), , pp.284-287
Hauptverfasser: Tanjung, Mulyadi, Nurmalasari, Intan, Wilujeng, Aisyah Kanti, Dewi Saputri, Ratih, Rachmadiarti, Fida, Srie Tjahjandarie, Tjitjik
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Sprache:eng
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약학
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Zusammenfassung:A new isoprenylated acetophenone, acronyculatin P (1) as well as two known compounds, 3',5'-diisoprenyl-2',4'-dihydroxy-6'-methoxyphenylethanone (2) and 3'-isoprenyl-2',4',6'-trihydroxyphenylethanone (3) were isolated from the stem bark of Acronychia pedunculata (L.) Miq. The structures were determined by HRESIMS, 1D and 2D NMR. The inhibitory activity of the isoprenylated acetophenone derivatives against murine leukemia P-388 cells showed compound 1 moderate activity with IC50 15.42 mM. KCI Citation Count: 2
ISSN:1226-3907
2288-9027
DOI:10.20307/NPS.2018.24.4.284