월경주기에 따른 치은열구액 내 염증지표의 변화: 예비 연구

Sex Hormones exert significant influence in body physiology throughout life. Some reports suggested increased sex hormone levels correlate with an increased prevalence of gingivitis. The objectives of this pilot study are to(1) address the link between menstrual cycle and MMP-9, MMP-8, IL-1β of gingival crevicular fluid during 4 weeks and (2) discuss the major biomarker of periodontal status. 7 female and 3 male volunteer who didn`t have smoking habit, medical and dental disease after informed consent, were seen twice a week for 4 weeks. GCF samples were collected and GCF levels of MMP-9, MMP-8, IL-1β were measured by enzyme-linked immunosorbent assay. The GCF levels of MMP-9, MMP-8, IL-1β had fluctuation according to menstrual cycle, but the changes of those were not significant by Friedman matched samples test. There is no difference between female and male subjects by Mann-Whitney U test. The correlation of MMP-8, MMP-9 and IL-1β showed strong by Spearman correlation(0.644-0.945). This study confirms menstrual cycle doesn`t influence the periodontium of healthy female subjects.