Matrix Metallopeptidase 2 Gene Polymorphism is Associated with Obesity in Korean Population

Matrix Metallopeptidase 2 Gene Polymorphism is Associated with Obesity in Korean Population

The aim of this study was to determine whether single nucleotide polymorphisms (SNPs) of matrix metallopeptidase 2 (MMP2) are associated with obesity. MMP2 is an enzyme with proteolytic activity against matrix and nonmatrix proteins, particularly basement membrane constituents. To identify the relat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The Korean journal of physiology & pharmacology 2008, 12(3), , pp.125-129
Hauptverfasser: Han, Dong Hee, Kim, Su Kang, Kang, Sungwook, Choe, Bong-Keun, Kim, Keon Sik, Chung, Joo-Ho
Format: Artikel
Sprache:eng
Schlagworte:
Original
약리학
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The aim of this study was to determine whether single nucleotide polymorphisms (SNPs) of matrix metallopeptidase 2 (MMP2) are associated with obesity. MMP2 is an enzyme with proteolytic activity against matrix and nonmatrix proteins, particularly basement membrane constituents. To identify the relationship between polymorphisms of MMP2 and overweight/obese, we genotyped 5 SNPs (rs17242319, rs1053605, rs243849, rs2287074, and rs10775332) of the coding region of MMP2 using the Golden Gate assay on an Illumina BeadStation 500 GX. One hundred and forty two overweight/obese (BMI >/=23) and 145 normal (BMI 18 to
ISSN:1226-4512
2093-3827
DOI:10.4196/kjpp.2008.12.3.125