Expression of pituitary adenylate cyclase activating polypeptide and its type I receptor mRNAs in human placenta

Pituitary adenylate cyclase activating polypeptide (PACAP) was first isolated from ovine hypothalamus and was known to stimulate the release of growth factor in various cells. Recently, we reported the cellular localization of PACAP and its type I (PAC₁) receptor in rat placenta during pregnancy. Pl...

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Veröffentlicht in:Journal of veterinary science (Suwŏn-si, Korea) 2005, 6(1), , pp.1-5
Hauptverfasser: Koh, P.O. (Gyeongsang National University, Jinju, Republic of Korea), Won, C.K. (Gyeongsang National University, Jinju, Republic of Korea), Noh, H.S. (Gyeongsang National University, Jinju, Republic of Korea), Cho, G.J. (Gyeongsang National University, Jinju, Republic of Korea), Choi, W.S. (Gyeongsang National University, Jinju, Republic of Korea), E-mail: choiws@nongae.gsnu.ac.kr
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Sprache:eng
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Zusammenfassung:Pituitary adenylate cyclase activating polypeptide (PACAP) was first isolated from ovine hypothalamus and was known to stimulate the release of growth factor in various cells. Recently, we reported the cellular localization of PACAP and its type I (PAC₁) receptor in rat placenta during pregnancy. Placenta is a critical organ that synthesizes several growth factors and angiogenic factors for the fetal development and its own growth. However, there is little information regarding the cellular localization of PACAP and its receptor in human placenta at various gestations. The aim of the present study was to define the expression and distribution of PACAP and PAC₁ receptor mRNAs in the human placenta during the pregnancy period.
ISSN:1229-845X
1976-555X
DOI:10.4142/jvs.2005.6.1.1